The Nanolucent Solution

Our technology will enable automated on the spot analysis of Pap smear slides with the results available within 30 minutes. Therefore, patients will receive results almost immediately, while avoiding up-charges related to positive tests, and stress due to delays.

Nanolucent diagnostics platform is based upon a secure and robust cloud-based AI platform, which will enable truly global use: i.e. a physician in Cape Town will receive results as quickly as one in New York or London - within minutes.

Current Process

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Nanolucent Process

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Currently, cervical cancer screening is the primary domain of the gynecology profession, whose numbers are shrinking steadily in the US and Canada, making access to a specialist more difficult especially in more rural areas of the countries.  However, the simple taking of a pap smear is a fast and routine process, and we believe that the Nanolucent CervChekTM system, because it produces rapid, manageable results, will lead to the fast adoption of cervical cancer screening by family doctors.  The amount of administration using our process will be very low, and it will be a fast, simple process to identify negative results, providing peace of mind to those who have no indication, and will prompt immediate action where tests show cellular irregularity.

Nanolucent innovations are powered by technology developed by Lucendi, Inc. - a company spin-off from the UCLA Ozcan Research Group and based in Los Angeles. Founded in 2016, Lucendi is a leading innovator of AI-based holographic measurement systems. Lucendi holographic technology re-defines microscopic imaging by offering a more powerful and cost-effective solution across many applications with a combined market of over $1 trillion.


Lucendi's technology has been supported by government agencies (i.e. NIH, NSF, EPA, DOE) and industry partners, and has been validated via developed prototypes and leading peer-reviewed publications. The core of the Lucendi technology platform is a fusion between the holographic imaging devices and deep learning algorithms for rapid data processing and characterization.  

Powered by Lucendi Technology

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Image taken from Lucendi's lab in California.

Functional Benchtop Prototype

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Left: Functional Benchtop Prototype. 
Right: Schematics of Functional Benchtop Prototype internal components.

Prototype Features:
 

• Functional benchtop prototype that leverages AI-based algorithms

• Optimization of image processing

• Automated and accurate classification and diagnostics of premalignant and/or malignant cells in  Pap tests

• Compact: ~145 grams

• Resolution: ~225-500nm

• Large field of view: ~20-30mm2 (100x larger than in a lens-based microscope)

• Generates, analyzes and archives images of the whole sample and abnormal cells

• Quarter coin for size reference

Preliminary Results

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  • Full field-of-view color reconstruction of a Pap test (ThinPrep preparation) with CervChek TM prototype device.

  • Side-by-side examples of an image produced by CervCheck TM and a 20X objective standard optical microscope.

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  • Top Row: Reconstructed color lensfree image of normal and abnormal cells (pointed with white arrows), which exhibit either irregular cytoplasm shape or irregular large nucleus in comparison to the cytoplasm.

  • Bottom Row: Microscope images obtained with a 20× objective lens (0.5NA)